反应详情

温度

90 °C

In a 20 mL microwave tube, a mixture of 2-(3-iodo-1-tosyl-1H-indol-5-yl)-5-phenyl-1,3,4-thiadiazole (493 mg, 0.884 mmol), bis(pinacolato)diboron (674 mg, 2.65 mmol), potassium acetate (434 mg, 4.42 mmol), PdCl2(dppf), complex with DCM (108 mg, 0.133 mmol) and DMF (4.0 mL) was stirred at 90° C. in the oil bath for 1 h. The mixture was treated with H2O, extracted with EtOAc (50 mL) and washed with brine (2×20 mL), dried over MgSO4, filtered and concentrated affording a brown oil which crystallized upon standing. It was used in the next step without further purification.

1. extractionextracted with EtOAc (50 mL)
2. washwashed with brine (2×20 mL)
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customaffording a brown oil which
7. customcrystallized
8. customIt was used in the next step without further purification