反应详情

1.55 g (12.3 mmol) of the furanacetic acid, 1.99 g (12.3 mmol) of 4-hydroxycoumarin and 2.83 g (13.7 mmol) of DCC were suspended in 50 ml of toluene, then 149 mg (1.22 mmol) of DMAP added and stirring carried out overnight at 60° C. The reaction liquid was then cooled to room temperature and the insoluble material filtered off. The mother liquor was concentrated and the residue purified by column chromatography. The solid obtained was recrystallized from methanol and Compound 9. (594 mg, 2.20 mmol, 18%) obtained. This was converted to the sodium salt with an equivalent amount of sodium hydrogen carbonate.

1. customThe reaction liquid
2. filtrationthe insoluble material filtered off
3. concentrationThe mother liquor was concentrated
4. customthe residue purified by column chromatography
5. customThe solid obtained
6. customwas recrystallized from methanol and Compound 9
7. custom(594 mg, 2.20 mmol, 18%) obtained