反应详情

1.76 g (10.0 mmol) of the 2-benzofuranacetic acid, 1.26 g (10.0 mmol) of 4-hydroxy-6-methyl-2-pyrone and 2.27 g (11.1 mmol) of DCC were suspended in 50 ml of chloroform, then 130 mg (1.06 mmol) of DMAP added and stirring carried out overnight at 60° C. The reaction liquid was cooled to room temperature and the insoluble material filtered off. The mother liquor was concentrated and the residue purified by column chromatography. The solid obtained was recrystallized from ethanol and Compound 15 (614 mg, 2.16 mmol, 21%) obtained. This was converted to the sodium salt with an equivalent quantity of sodium hydrogen carbonate.

1. customThe reaction liquid
2. filtrationthe insoluble material filtered off
3. concentrationThe mother liquor was concentrated
4. customthe residue purified by column chromatography
5. customThe solid obtained
6. customobtained