Hydrochloric Acid → HCID 178478642, compound

HRID 635309Notes

Reaction equation

HRID 635309 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[N:14]1[NH:15][C:16]([CH2:23][CH2:24][C:25](O)=[O:26])=[C:17]2[C:22]=1[CH2:21][CH2:20][CH2:19]C2.[Cl:28]C1C=CC(C2CCNCC2)=CC=1.[ClH:41]>>[OH2:26].[OH2:26].[ClH:28].[ClH:41].[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:25][CH2:24][CH2:23][C:16]3[NH:15][N:14]=[C:22]4[CH2:21][CH2:20][CH2:19][C:17]=34)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 752601-(4-Fluorophenyl)piperazineHCID 12036134-(4-Chlorophenyl)piperidineHCID 1785253693-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid

Product 1

HCID 178478642HCID 178478642, compound

Procedure

In the same manner as in Example 102 except that 3-(2,4,5,6-tetrahydrocyclopentapyrazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 4 and 1-(4-fluorophenyl)piperazine were used instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 1 and 4-(4-chlorophenyl)piperidine and then by a conventional treatment using hydrochloric acid, 3-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-2,4,5,6-tetrahydrocyclopentapyrazole dihydrochloride dihydrate was obtained, m.p. 228-230° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-0896f477a6214dfbb95faaad83768430
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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