反应详情

温度

23 °C

N-phenylacetyl-L-methionine (0.1285 g, 0.447 mmol) was dissolved in 3.0 mL dioxane and iso-butyl alcohol (0.2 mL) and treated with EDC (0.094 g, 0.492 mmol), and catalytic DMAP (0.015 g). After stirring for 17 hours at 23° C., the mixture was evaporated at reduced pressure to an oil, the residue was diluted in EtOAc and washed with 0.1 N HCl and saturated sodium bicarbonate. Chromatography on silica gel using 98:2 CHCl3/MeOH as eluant provided the pure product.

1. customthe mixture was evaporated at reduced pressure to an oil
2. additionthe residue was diluted in EtOAc
3. washwashed with 0.1 N HCl and saturated sodium bicarbonate
4. customChromatography on silica gel using 98:2 CHCl3/MeOH as eluant provided the pure product