Trifluoroacetic acid → HCID 18464792, compound

HRID 637242Notes

Reaction equation

HRID 637242 reaction equation
[F:1][C:2]([O:5][CH2:6][CH2:7]OCC1C=CC(Br)=CC=1)([F:4])[F:3].C1(SC)C=CC=CC=1.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].C(=O)(O)[O-].[K+].[O-]S([O-])(=O)=O.[Mg+2]>C(Cl)(Cl)Cl>[F:1][C:2]([O:5][CH2:6][CH2:7][O:28][C:27](=[O:29])[C:26]([F:31])([F:30])[F:25])([F:4])[F:3]

Participants

7

Reactant 5

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 24083Sulfuric acid magnesium salt (1:1)HCID 516893Potassium BicarbonateHCID 18464551HCID 18464551, compound

Product 1

HCID 18464792HCID 18464792, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Combine 2-(4-bromobenzyloxy)ethyl trifluoromethyl ether (2.4 g, 8.1 mmol), thioanisole (28.5 mL, 243 mmol), and trifluoroacetic acid (30 mL). After 24 hours, add potassium bicarbonate to neutralize. Add MgSO4 and chloroform (30 mL). Filter and distill through a short path distillation apparatus to give 2-(trifluoroacetoxy)ethyl trifluoromethyl ether containing chloroform which can be used without further purification.

Workup

  1. filtrationFilter
  2. distillationdistill through a short path distillation apparatus

Sources & evidence

ORD record
ord-fa7260bd6b30444fbdbb8f914d2cf58f
Source dataset
uspto-grants-2001_02
Patent number
US06194406B1

Reaction notes

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