Hydrochloric Acid → HCID 70381945, compound

HRID 637354Notes

Reaction equation

HRID 637354 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]([NH2:13])=[O:12])[C:6](=[O:14])[CH2:5]2.[C:15](Cl)(=[O:17])[CH3:16].Cl>CN(C1C=CN=CC=1)C>[C:15]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]([NH2:13])=[O:12])[C:6](=[O:14])[CH2:5]2)(=[O:17])[CH3:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 13647649HCID 13647649, compound

Product 1

HCID 70381945HCID 70381945, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

A slurry of 0.5 g. (2.6 mmole) of 5-amino-2-oxindole-1-carboxamide and 0.35 g. of 4-(N,N-dimethylamino)pyridine was stirred at 10° C., and then 0.20 ml. (2.8 mmole) of acetyl chloride was added. Stirring was continued at ca -10° C. for 20 minutes and at room temperature for 15 minutes, and then 20 ml. of 1N hydrochloric acid was added. The solid was recovered by filtration, and dried, to give 0.20 g. of the title compound as a cream-colored solid.

Workup

  1. filtrationThe solid was recovered by filtration
  2. customdried
  3. customto give 0.20 g

Sources & evidence

ORD record
ord-2aa920cd1fdc4d229c7bdd4c68b8530d
Source dataset
uspto-grants-1985_12
Patent number
US04556672

Reaction notes

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