2-Methyl-2-thiopseudourea → HCID 20221228, compound

HRID 637747Notes

Reaction equation

HRID 637747 reaction equation
CS[C:3](=[NH:5])[NH2:4].[NH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12].[H-].[Na+]>O1CCCC1>[NH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][C:3](=[NH:5])[NH2:4]

Participants

5

Reactant 3

HCID 51422-Methyl-2-thiopseudoureaHCID 24758Sodium hydrideHCID 756345-Aminopentan-1-ol

Product 1

HCID 20221228HCID 20221228, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

S-Methylisothiourea is reacted with 5-aminopentanol and sodium hydride in tetrahydrofuran to give O-(5-aminopentyl)isourea, which is reacted with 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone in refluxing ethanol to give 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Sources & evidence

ORD record
ord-02d9536bf6d84c6cbbeb3034a8cbb754
Source dataset
uspto-grants-1985_12
Patent number
US04558128

Reaction notes

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