Chloroacetone → HCID 3041219, compound

HRID 637914Notes

Reaction equation

HRID 637914 reaction equation
[Cl:1][CH2:2][C:3](=O)[CH3:4].C([O-])(O)=O.[Na+].Cl.[NH2:12][NH:13][C:14]([NH2:16])=[O:15]>O.C1COCC1>[N:12](=[C:3]([CH3:4])[CH2:2][Cl:1])[NH:13][C:14]([NH2:16])=[O:15]

Participants

6

Reactant 3

HCID 6571ChloroacetoneHCID 11236Semicarbazide hydrochlorideHCID 516892Sodium Bicarbonate

Product 1

HCID 3041219HCID 3041219, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Add 1.0 gm chloroacetone and a solution of 0.84 gm NaHCO3 in 10 ml water to a solution of 1.1 gm semicarbazide hydrochloride in 25 ml THF and stir overnight. Two layers form. Separate the top layer and concentrate to obtain an off-white solid, 2-semicarbazono-1-chloropropane.

Workup

  1. customTwo layers form
  2. customSeparate the top layer
  3. concentrationconcentrate

Sources & evidence

ORD record
ord-0888216fb9a84cc985b2636845a58eb5
Source dataset
uspto-grants-1985_12
Patent number
US04559333

Reaction notes

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