L-Methionine → HCID 136041194, compound

HRID 638039Notes

Reaction equation

HRID 638039 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][C:10]([O:13]C)=[CH:9][CH:8]=2)=[N:5][C:4]([S:15][CH3:16])=[N:3]1.N[C@H](C(O)=O)CCSC.CS(O)(=O)=O>C(O)(C)C>[OH:13][C:10]1[CH:9]=[CH:8][C:7]([C:6]2[N:2]([CH3:1])[N:3]=[C:4]([S:15][CH3:16])[N:5]=2)=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 6137L-MethionineHCID 6395Methanesulfonic AcidHCID 20255192HCID 20255192, compound

Product 1

HCID 136041194HCID 136041194, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Analogously to Example (15b), a mixture of 49.6 g of 1-methyl-3-methylthio-5-(4-methoxyphenyl)-1H-1,2,4-triazole, 40 g of L-methionine and 380 ml of methanesulphonic acid is heated for 24 hours in a bath at 110°-120° and analogously worked up, yielding 5-(4-hydroxyphenyl)-1-methyl-3-methylthio-1H-1,2,4-triazole having a melting point of 216°-220° (from isopropanol).

Workup

  1. temperatureis heated for 24 hours in a bath at 110°-120°

Sources & evidence

ORD record
ord-85266e82548740f88bc003124e44c9af
Source dataset
uspto-grants-1985_12
Patent number
US04559354

Reaction notes

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