反应详情

The compound of Example 31A (180 mg, 1.02 mmol) is dissolved in tetrahydrofuran (8 ml). Lithium hydroxide (48.94 mg, 2.04 mmol) is dissolved in water (5 ml) and added to the THF solution. The reaction is stirred for 2 hours at room temperature. The mixture is diluted with water and ethyl acetate. The aqueous phase is extracted three times with ethyl acetate. The organic phases are combined and washed with brine, dried with magnesium sulphate monohydrate, filtered and concentrated in vacuo. The residue is used without further purification.

1. extractionThe aqueous phase is extracted three times with ethyl acetate
2. washwashed with brine
3. dry with materialdried with magnesium sulphate monohydrate
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe residue is used without further purification