Succinic anhydride → 3-(2-Thenoyl)propionic acid

HRID 639762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639762
[S:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[C:6]1(=[O:12])[O:11][C:9](=[O:10])[CH2:8][CH2:7]1.[Cl-].[Al+3].[Cl-].[Cl-]>ClC(Cl)C.O.Cl>[O:12]=[C:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:7][CH2:8][C:9]([OH:11])=[O:10]

Komponenten

7

Edukt 3

HCID 7922Succinic anhydrideHCID 8030ThiopheneHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 783853-(2-Thenoyl)propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 962WaterLösungsmittelHCID 63651,1-DichloroethaneLösungsmittel

Versuchsvorschrift

Thiophene (5.0 gm, 0.059 moles) and succinic anhydride (7.13 gm, 0.0713 moles) were taken up in dichloroethane (50 ml). Aluminium chloride (17.43 gm, 0.131 moles) was added at room temperature and the resulting mixture heated under reflux for 1 hr with stirring. The reaction mixture was cooled to room temperature, diluted with 30 ml of 1:1 mixture of water and Conc. hydrochloric acid. After stirring for 10 min the separated solid was filtered under suction, washed with water and dilute hydrochloric acid (50 ml). The solid was dried at room temp to give 9.8 gm (89%0 of the title compound, mp 103-107° C.

Aufarbeitung

  1. temperaturethe resulting mixture heated
  2. temperatureunder reflux for 1 hr
  3. stirringAfter stirring for 10 min the separated solid
  4. filtrationwas filtered under suction
  5. washwashed with water and dilute hydrochloric acid (50 ml)
  6. customThe solid was dried at room temp

Quellen und Nachweise

ORD-Eintrag
ord-71bd1d2864194cd890ecf08a22ac241f
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691889B2

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