Dimethylformamide → HCID 11589364, compound

HRID 639822Notes

Reaction equation

HRID 639822 reaction equation
I[C:2]1[CH:3]=[C:4]([N:8]2[N:12]=[N:11][C:10]([CH2:13][N:14]3[C:23]4[N:19]([C:20]([C:24]5[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=5)=[N:21][N:22]=4)[CH2:18][CH2:17][CH2:16][CH2:15]3)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:30][N:31](C=O)C>[C-]#N.[Zn+2].[C-]#N>[N:27]1[CH:28]=[CH:29][C:24]([C:20]2[N:19]3[C:23]([N:14]([CH2:13][C:10]4[N:11]=[N:12][N:8]([C:4]5[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=5)[C:30]#[N:31])[N:9]=4)[CH2:15][CH2:16][CH2:17][CH2:18]3)=[N:22][N:21]=2)=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 11670535HCID 11670535, compound

Product 1

HCID 11589364HCID 11589364, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

The title compound is prepared from 8-[2-(3-iodo-phenyl)-2H-tetrazol-5-ylmethyl]-3-pyridin-4-yl-5,6,7,8-tetrahydro-4H-1,2,3a,8-tetraaza-azulene (1 mmol), zinc cyanide (1.1 mmol), palladium (0) tetrakis-triphenylphosphine (0.05 mmol) in DMF (5 mL) at 80° C. overnight.

Sources & evidence

ORD record
ord-c8bd42a8c5434cc9a43b4a49dd77dc13
Source dataset
uspto-grants-2010_04
Patent number
US07691892B2

Reaction notes

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