反应详情

温度

70 °C

Nicotinohydrazide (10 g, 73 mmol) and methyl isothiocyanate (5.6 g, 76 mmol) were mixed in 2-propanol (150 ml) and heated to 70° C. o.n. The reaction was cooled to r.t. and evaporated to dryness. H2O (180 mL) and NaHCO3 (12.8 g, 152 mmol) were added to the residue and the mixture was refluxed o.n. The reaction mixture was cooled to r.t., acidified with concentrated HCl and the title compound, 13.1 g (93%), was collected by filtration. LC-MS (M++1): 193

1. temperatureThe reaction was cooled to r.t.
2. customevaporated to dryness
3. temperaturethe mixture was refluxed o.n
4. temperatureThe reaction mixture was cooled to r.t.
5. filtrationthe title compound, 13.1 g (93%), was collected by filtration