反应详情

To a solution of piperidine (3.4 g, 40.7 mmol, 1.0 eq) in DMF were added K2CO3 (14 g, 101.0 mmol, 2.5 eq.) and ethyl 2-chloroacetate (4.83 ml, 48.9 mmol, 1.2 eq). The mixture was stirred at RT for 16 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to give the product in 72% yield (5 g). LC-MS (ESI): Calculated mass: 171.1; Observed mass 172.3 [M+H]+ (rt: 0.1 min).

1. customThe mixture was quenched
2. extractionextracted as in Intermediate Example 5(a)
3. distillationThe solvent was distilled off
4. customto give the product in 72% yield (5 g)
5. customObserved mass 172.3 [M+H]+ (rt: 0.1 min)