反应详情

2-Morpholino-4,6-dichloropyrimidine (2.34 g; 10 mmol) and ethyl glycolate (1.3 g; 12 mmol) were dissolved in tetrahydrofuran (100 mL), and chilled in an ice bath. To the solution was added sodium hydride (300 mg; 12 mmol), and it was stirred overnight at ambient temperature. The solvents were evaporated, and the solid was dissolved in ethyl acetate (200 mL) which was then washed with water (2×100 mL). The organic layer was dried over magnesium sulfate, and evaporated to give (6-chloro-2-morpholin-4-yl-pyrimidin-4-yloxy)-acetic acid ethyl ester (3.16 g).

1. temperaturechilled in an ice bath
2. customThe solvents were evaporated
3. dissolutionthe solid was dissolved in ethyl acetate (200 mL) which
4. washwas then washed with water (2×100 mL)
5. dry with materialThe organic layer was dried over magnesium sulfate
6. customevaporated