2-Butene, 1-bromo-3-methyl- → 3-Methyl-7-(3-methyl-2-buten-1-yl)-8-bromo-xanthine

HRID 641353Notes

Reaction equation

HRID 641353 reaction equation
CCN(C(C)C)C(C)C.[CH3:10][C:11]([CH3:15])=[CH:12][CH2:13]Br.[CH3:16][N:17]1[C:25]2[N:24]=[C:23]([Br:26])[NH:22][C:21]=2[C:20](=[O:27])[NH:19][C:18]1=[O:28]>CN(C)C=O.O>[CH3:16][N:17]1[C:25]2[N:24]=[C:23]([Br:26])[N:22]([CH2:13][CH:12]=[C:11]([CH3:15])[CH3:10])[C:21]=2[C:20](=[O:27])[NH:19][C:18]1=[O:28]

Participants

6

Reactant 3

HCID 700922-Butene, 1-bromo-3-methyl-HCID 81531DiisopropylethylamineHCID 15487978-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione

Product 1

HCID 34353313-Methyl-7-(3-methyl-2-buten-1-yl)-8-bromo-xanthine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

15.37 ml of Hünig base and 9.98 ml of 3,3-dimethylallylbromide are added to 20.00 g of 3-methyl-8-bromo-xanthine in 200 ml of N,N-dimethylformamide. The reaction mixture is stirred for about half an hour at ambient temperature and then diluted with 500 ml of water. The precipitate formed is suction filtered, washed with water and dried.

Workup

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-cac098f67e724de69b623b11972842d7
Source dataset
uspto-grants-2010_04
Patent number
US07696212B2

Reaction notes

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