Methyl 3-amino-2-thiophenecarboxylate → 3-amino-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide

To a stirred solution of 4-trifluoromethoxyaniline (7.8 g, 44.5 mmol) in toluene (50 mL) under nitrogen was added trimethylaluminum (2M in toluene, 26.7 mL, 53.4 mmol). The mixture was stirred at RT for 16 h. Methyl 3-amino-2-thiophenecarboxylate (7 g, 44.5 mmol) was added and the resulting solution was stirred at reflux (oil bath temperature: 130° C.) under nitrogen for 24 h. After cooling to RT, saturated sodium bicarbonate solution (100 mL) was added dropwise with caution and the mixture was stirred at RT for 30 min. The product was extracted into dichloromethane (3×100 mL), and the organic layer was dried over Na2SO4, and concentrated to yield a thick oil, which was then triturated with a mixture of hexane/ethyl acetate to afford N-(4-trifluoromethoxyphenyl) 3-Aminothiophene-2-carboxamide as a brown solid. 1H-NMR (400 MHz/CD3OD): δ=6.65 (d, J=5.6 Hz, 1H), 7.23 (d, J=8.4 Hz, 2H), 7.39 (d, J=5.2 Hz, 1H), 7.67 (d, J=9.2 Hz, 2H). MS (ES+): 303 [MH+].

1. stirringthe resulting solution was stirred
2. temperatureat reflux (oil bath temperature: 130° C.) under nitrogen for 24 h
3. temperatureAfter cooling to RT
4. stirringthe mixture was stirred at RT for 30 min
5. extractionThe product was extracted into dichloromethane (3×100 mL)
6. dry with materialthe organic layer was dried over Na2SO4
7. concentrationconcentrated
8. customto yield a thick oil, which
9. customwas then triturated with a mixture of hexane/ethyl acetate

ORD record

ord-0536e045af43470a9a8591a5898b3b45

Source dataset

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07696225B2