Triethylsilane → HCID 68577977, compound

HRID 642675Notes

Reaction equation

HRID 642675 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[C:15]([C:17]1[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=[CH:19][CH:18]=1)=O)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])[CH3:2].C([SiH](CC)CC)C>FC(F)(F)C(O)=O>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[CH2:15][C:17]1[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=[CH:19][CH:18]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 12052TriethylsilaneHCID 68578556HCID 68578556, compound

Product 1

HCID 68577977HCID 68577977, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2. To a solution of 3-(naphthalene-1-carbonyl)-1H-indole-2-carboxylic acid ethyl ester (0.81 g) in trifluoroacetic acid (3.6 ml) was added triethylsilane (1.5 ml) and stirring was continued at 22° C. for 21 h. The suspension was filtered, the residue washed with n-heptane and dried to give 3-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid ethyl ester as a white solid. MS: 328.1 ([M−H]−).

Workup

  1. filtrationThe suspension was filtered
  2. washthe residue washed with n-heptane
  3. customdried

Sources & evidence

ORD record
ord-9cdc923ef8c94c118addd54d147844e9
Source dataset
uspto-grants-2010_04
Patent number
US07696240B2

Reaction notes

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