Hydrochloric Acid → HCID 123608631, compound

HRID 643062Notes

Reaction equation

HRID 643062 reaction equation
[CH2:1]([C@H:8]([NH:33]C(=O)OC(C)(C)C)[C@@H:9]([OH:32])[CH2:10][N:11]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:12][C:13](=[O:24])[C@@H:14]([NH:19][C:20]([O:22][CH3:23])=[O:21])[C:15]([CH3:18])([CH3:17])[CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C1COCC1>[NH2:33][C@@H:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C@@H:9]([OH:32])[CH2:10][N:11]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:12][C:13]([C@@H:14]([NH:19][C:20](=[O:21])[O:22][CH3:23])[C:15]([CH3:18])([CH3:17])[CH3:16])=[O:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68294422HCID 68294422, compound

Product 1

HCID 123608631HCID 123608631, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

A solution of Example 5F in THF (4 mL) was treated with 4N HCl, and stirred at 70° C. for 3 hrs. The mixture was cooled to room temperature and quenched with saturated sodium bicarbonate and ethyl acetate. The organic layer was separated, washed with brine, dried over sodium sulfate, filtered and the solvents were evaporated to give 83 mg (100%) of the title compound.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. customquenched with saturated sodium bicarbonate and ethyl acetate
  3. customThe organic layer was separated
  4. washwashed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. customthe solvents were evaporated

Sources & evidence

ORD record
ord-51d6f924452e41ac81a0ec95cfce4330
Source dataset
uspto-grants-2010_04
Patent number
US07696226B2

Reaction notes

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