反应详情

温度

50 °C

A mixture of 5-bromo-2-fluorobenzoic acid (25 g, 0.11 mol), methyl iodide (8.5 mL, 0.14 mol), and potassium carbonate (31 g, 0.23 mol) in DMF (200 mL) was heated to 50° C. for 18 hr. The cooled reaction mixture was diluted with EtOAc (200 mL) and the organic phase was washed with a saturated aqueous NaCl solution (4×). The organic phase was then dried over sodium sulfate and evaporated to dryness to give 24g of methyl 5-bromo-2-fluorobenzoate as a yellow oil. Step B:

1. customThe cooled reaction mixture
2. washthe organic phase was washed with a saturated aqueous NaCl solution (4×)
3. dry with materialThe organic phase was then dried over sodium sulfate
4. customevaporated to dryness