Methane → HCID 11408320, compound

HRID 643650Notes

Reaction equation

HRID 643650 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]1[C@@H:10]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[CH2:9][C@H:8]2[NH:19][C@@H:5]1[CH2:6][CH2:7]2.[C:20]([OH:29])(=[O:28])[C@@H:21]([C@H:23]([C:25]([OH:27])=[O:26])[OH:24])[OH:22].C>C(O)C>[CH3:1][O:2][CH2:3][C@@H:4]1[C@@H:10]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[CH2:9][C@H:8]2[NH:19][C@@H:5]1[CH2:6][CH2:7]2.[OH2:22].[C:25]([C@@H:23]([C@H:21]([C:20]([OH:29])=[O:28])[OH:22])[OH:24])([OH:27])=[O:26].[CH3:1][O:2][CH2:3][C@@H:4]1[C@@H:10]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[C:13]([Cl:18])[CH:12]=2)[CH2:9][C@H:8]2[NH:19][C@@H:5]1[CH2:6][CH2:7]2

Participants

6

Reactant 3

HCID 297MethaneHCID 444305L-Tartaric acidHCID 11408320HCID 11408320, compound

Product 2

HCID 11408320HCID 11408320, compoundHCID 67481247HCID 67481247, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a heated solution of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane (the free base) in aqueous ethanol was added L-tartaric acid. The warm mixture was treated with activated charcoal and filtered. The filtrate was cooled and (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo-[3.2.1]octane was isolated as the L-tartrate monohydrate.

Workup

  1. filtrationfiltered
  2. temperatureThe filtrate was cooled

Sources & evidence

ORD record
ord-660a47fde6dc4b599968f2185b786729
Source dataset
uspto-grants-2010_04
Patent number
US07700619B2

Reaction notes

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