反应详情

温度

60 °C

A mixture of 1-iodopropane (1.87 g, 10.98 mmol), methyl orsellinate (2.0 g, 10.98 mmol), and sodium bicarbonate (1.84 g, 21.96 mmol) in DMF is stirred at 60° C. overnight. The mixture is cooled and partitioned between EtOAc and water. The EtOAc layer is washed with brine, dried over magnesium sulfate, and concentrated to give the crude product. Purification by silica gel chromatography using 2% EtOAc in hexane as the eluent gives 2-hydroxy-6-methyl-4-propoxy-benzoic acid methyl ester.

1. temperatureThe mixture is cooled
2. custompartitioned between EtOAc and water
3. washThe EtOAc layer is washed with brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customto give the crude product
7. customPurification by silica gel chromatography