反应详情

温度

5 °C

3.3 mL ethyldiisopropyl-amine and 2.06 g (12.6 mmol) of CDT were added to an ice-cooled solution of 2.95 g (12.54 mmol) of methyl 2-amino-3-(3,4-diethyl-phenyl)-propionate in 200 mL of THF and stirred for a further 90 min at 0-10° C. Then 20 mL of DMF were added, the mixture was stirred for a further 30 min, 2.91 g (12.6 mmol) of 3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one were added and the suspension was refluxed for 10 h. The reaction mixture was evaporated down in vacuo, combined with semisaturated NaHCO3 solution, exhaustively extracted with EtOAc and dried over MgSO4. After elimination of the desiccant and solvent the crude product was reacted without any further purification.

1. stirringthe mixture was stirred for a further 30 min
2. temperaturethe suspension was refluxed for 10 h
3. customThe reaction mixture was evaporated down in vacuo
4. extractionexhaustively extracted with EtOAc
5. dry with materialdried over MgSO4
6. customAfter elimination of the desiccant and solvent the crude product was reacted without any further purification