Ethyl chloroformate → HCID 58662430, compound

HRID 644816Notes

Reaction equation

HRID 644816 reaction equation
C([O-])([O-])=O.[K+].[K+].[CH2:7]([CH:9]1[CH2:18][C:17](=[O:19])[C:16]2[C:11](=[C:12]([CH3:21])[N:13]=[C:14]([CH3:20])[CH:15]=2)[NH:10]1)[CH3:8].Cl[C:23]([O:25][CH2:26][CH3:27])=[O:24]>C1COCC1>[CH2:26]([O:25][C:23]([N:10]1[C:11]2[C:16](=[CH:15][C:14]([CH3:20])=[N:13][C:12]=2[CH3:21])[C:17](=[O:19])[CH2:18][CH:9]1[CH2:7][CH3:8])=[O:24])[CH3:27]

Participants

5

Reactant 3

HCID 10928Ethyl chloroformateHCID 11430Potassium CarbonateHCID 58662440HCID 58662440, compound

Product 1

HCID 58662430HCID 58662430, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

This compound can be obtained by reacting a suspension of K2CO3 (3-5 eqv) in THF with a solution of 2-ethyl-6,8-dimethyl-2,3-dihydro-1H-[1,7]naphthyridin-4-one in THF and ethyl chloroformate (1.5 to 2 eqv), typically at a temperature from about RT to about 50° C., followed by a typical workup procedure.

Workup

  1. customThis compound can be obtained
  2. customfrom about RT to about 50° C.

Sources & evidence

ORD record
ord-163bd8070ba94b1084db943b308ef5b8
Source dataset
uspto-grants-2010_04
Patent number
US07700774B2

Reaction notes

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