Methyl chloroformate → HCID 11526955, compound

HRID 644819Notes

Reaction equation

HRID 644819 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[C:15]2[C:10](=[CH:11][C:12]([CH3:17])=[N:13][C:14]=2[CH3:16])[CH:9]([NH:18][CH2:19][C:20]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[C:22]([C:30]([F:33])([F:32])[F:31])[CH:21]=2)[CH2:8][CH:7]1[CH2:34][CH3:35])=[O:5])[CH3:2].C([O-])([O-])=O.[K+].[K+].Cl[C:43]([O:45][CH3:46])=[O:44]>C1COCC1>[CH2:1]([O:3][C:4]([N:6]1[C:15]2[C:10](=[CH:11][C:12]([CH3:17])=[N:13][C:14]=2[CH3:16])[CH:9]([N:18]([CH2:19][C:20]2[CH:25]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:23]=[C:22]([C:30]([F:33])([F:31])[F:32])[CH:21]=2)[C:43]([O:45][CH3:46])=[O:44])[CH2:8][CH:7]1[CH2:34][CH3:35])=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 11430Potassium CarbonateHCID 58662428HCID 58662428, compound

Product 1

HCID 11526955HCID 11526955, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound can be prepared by reacting, a solution of 4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-6,8-dimethyl-3,4-dihydro-2H-[1,7]naphthyridine-1-carboxylic acid ethyl ester in THF and K2CO3 (2 to 5 eqv) with methyl chloroformate, followed by a typical workup procedure.

Workup

  1. customThis compound can be prepared

Sources & evidence

ORD record
ord-3d15413279a94b3782aa8b244e0e2a9a
Source dataset
uspto-grants-2010_04
Patent number
US07700774B2

Reaction notes

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