4-Bromophenol → HCID 65457361, compound

HRID 646108Notes

Reaction equation

HRID 646108 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][CH:11]1[CH2:14][CH2:13][CH2:12]1.[OH-].[Na+]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH:11]2[CH2:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 78084-BromophenolHCID 14798Sodium HydroxideHCID 2734658(Bromomethyl)cyclobutane

Product 1

HCID 65457361HCID 65457361, compoundYield 37.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Bromophenol (2.5 g, 14.5 mmol), (bromomethyl)cyclobutane (1.6 mL, 15 mmol), sodium hydroxide (0.8 g, 20 mmol) and DMF (3 mL) were allowed to react to yield the sub-title compound (1.3 g, 36%).

Workup

  1. customto react

Sources & evidence

ORD record
ord-1d56950fb7fd4104928752ce6c6d8144
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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