Methanol → HCID 56945267, compound

HRID 646123Notes

Reaction equation

HRID 646123 reaction equation
[Br:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8](Cl)=[O:9])=[CH:4][CH:3]=1.[CH3:15][OH:16].CCN(CC)CC>C1COCC1>[CH3:15][O:16][C:8](=[O:9])[C:7]([O:6][C:5]1[CH:13]=[CH:14][C:2]([Br:1])=[CH:3][CH:4]=1)([CH3:12])[CH3:11]

Participants

5

Reactant 3

HCID 887MethanolHCID 8471TriethylamineHCID 45923264HCID 45923264, compound

Product 1

HCID 56945267HCID 56945267, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

2-(4-Bromophenoxy)-2-methylpropanoyl chloride (2.34 g, 8.4 mmol) in THF (10 mL) was added dropwise whilst stirring to anhydrous MeOH (1.34 g, 42 mmol), Et3N (1.7 g, 16.8 mmol) and THF at 0° C. The mixture was stirred at room temperature for 3 h, concentrated and distilled to afford the sub-title compound (1.74 g, 97%).

Workup

  1. concentrationconcentrated
  2. distillationdistilled

Sources & evidence

ORD record
ord-a515af214adf4272be56060636005517
Source dataset
uspto-grants-2010_04
Patent number
US07705023B2

Reaction notes

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