反应详情

温度

0 °C

A solution of 0.638 g of α,α-bis(4-chlorophenyl)-1H-pyrazole-3-methanol in 15 ml of trifluoroacetic acid was cooled to 0° C. Under a nitrogen atmosphere, 0.464 g of triethylsilane in 1 ml of methylene chloride was added. After stirring for 1 hour at 0° C., the mixture was poured into water, treated with sodium bicarbonate, and extracted with ethyl acetate. The ethyl acetate extract was dried, filtered, and evaporated to provide 428 mg of the title product (base) as a colorless oil. The residue was dissolved in ether, dry hydrogen chloride was added, and the title product was recovered by filtration providing white crystals with a melting point of 155°-165° C.

1. extractionextracted with ethyl acetate
2. extractionThe ethyl acetate extract
3. customwas dried
4. filtrationfiltered
5. customevaporated