Oxalyl chloride → HCID 178521105, compound

HRID 646409Notes

Reaction equation

HRID 646409 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[NH:6][C:7]([C:9]3[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][CH:10]=3)=[N:8][C:4]=2[CH:3]=1.C(Cl)(=O)C([Cl:23])=O>ClCCl.CN(C)C=O>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[NH:6][C:7]([C:9]3[CH:17]=[CH:16][C:12]([C:13]([Cl:23])=[O:14])=[CH:11][CH:10]=3)=[N:8][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 178524231HCID 178524231, compound

Product 1

HCID 178521105HCID 178521105, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 4-(5-chloro-1H-benzoimidazol-2-yl)-benzoic acid (1.0 mmol) (CAS 204514-08-9) and oxalyl chloride (2.0 mmol) in dichloromethane (0.10M), add 2 drops of dimethylformamide as a catalyst. Stir at room temperature for 2 hours. After this time, concentrate the reaction in vacuo. Assume total conversion to the acid chloride.

Workup

  1. concentrationAfter this time, concentrate
  2. customthe reaction in vacuo

Sources & evidence

ORD record
ord-091098fe97404f5785376115cb8f1021
Source dataset
uspto-grants-2010_04
Patent number
US07705025B2

Reaction notes

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