反应详情

5-bromouracil (30 g, 0.16 mole) was added to a flask containing 130 ml of POCl3. The mixture was heated at reflux for 4 days. During this time the reaction contents were protected from atmospheric moisture; HCl gas was evolved and the solution became homogeneous. Excess POCl3 was removed by distillation at atmospheric pressure. Continued distillation at reduced pressure afforded the title compound, bp 85°-90°/4 mm (29.7 g, 82% yield).

1. temperatureThe mixture was heated
2. temperatureat reflux for 4 days
3. customDuring this time the reaction contents
4. customExcess POCl3 was removed by distillation at atmospheric pressure
5. distillationContinued distillation at reduced pressure