Benzyl Bromide → HCID 20484309, compound

HRID 647946Notes

Reaction equation

HRID 647946 reaction equation
[CH2:1]([N:8]1[CH2:24][CH2:23][C:11]2[NH:12][C:13]3[C:18]([C:10]=2[CH2:9]1)=[C:17]1[C:19]([CH3:22])=[CH:20][S:21][C:16]1=[CH:15][CH:14]=3)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:25](Br)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[H-].[Na+]>CN(C)P(=O)(N(C)C)N(C)C>[CH2:25]([N:12]1[C:13]2[C:18](=[C:17]3[C:19]([CH3:22])=[CH:20][S:21][C:16]3=[CH:15][CH:14]=2)[C:10]2[CH2:9][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:24][CH2:23][C:11]1=2)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 20484284HCID 20484284, compound

Product 1

HCID 20484309HCID 20484309, compound

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

The compound is formed analogously to that described in Example 28, from 3.3 g of 9-benzyl-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole and 2 ml of benzyl bromide in 50 ml of hexamethylphosphoric acid triamide in the presence of NaH. Melting point: 206° C.

Workup

  1. customThe compound is formed analogously to that

Sources & evidence

ORD record
ord-accb3025a1394a01abfec8a12352de68
Source dataset
uspto-grants-1983_10
Patent number
US04410536

Reaction notes

Loading…