Butyl Chloride → Butyl ether

HRID 648364Notes

Reaction equation

HRID 648364 reaction equation
[Mg:1].[CH2:2]([O:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][CH2:4][CH3:5].C([Cl:15])CCC>>[CH2:2]([O:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][CH2:4][CH3:5].[CH2:2]([Mg:1][Cl:15])[CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 3

HCID 8005Butyl ChlorideHCID 8909Butyl etherHCID 5462224Magnesium

Product 2

HCID 8909Butyl etherHCID 178418265HCID 178418265, compound

Procedure

To a 1-liter flask equipped with a stirrer, a reflux condenser and a dropping funnel was added magnesium chip (12 g) for Grignard reagent. After replacing atmosphere in the flask by argon, di-n-butyl ether (250 ml) was added, and then n-butyl chloride (62 ml, 1.2 times by mole based on magnesium) was added dropwise to start reaction with the contents of the falsk kept at 50° C. After addition over 2 hours at 50° C., reaction was continued at this temperature for further 5 hours to obtain a di-n-butyl ether solution of n-butylmagnesium chloride. The concentration of this solution was 1.45 mole/liter.

Workup

  1. customTo a 1-liter flask equipped with a stirrer, a reflux condenser and a dropping funnel
  2. additionwas added
  3. customreaction with the contents of the falsk
  4. customkept at 50° C
  5. additionAfter addition over 2 hours at 50° C.
  6. customreaction

Sources & evidence

ORD record
ord-8540a65eae944685815b1ce20b905c12
Source dataset
uspto-grants-1983_10
Patent number
US04412049

Reaction notes

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