Hydrochloric Acid → HCID 54018226, compound

HRID 648774Notes

Reaction equation

HRID 648774 reaction equation
Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[OH:14][N:15]=[C:16]([C:23]#[N:24])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.Cl>O1CCCC1>[C:9]([C:8]1[CH:12]=[CH:13][C:5]([S:2]([O:14][N:15]=[C:16]([C:23]#[N:24])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)(=[O:4])=[O:3])=[CH:6][CH:7]=1)([OH:11])=[O:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 699982-(Hydroxyimino)-2-phenylacetonitrileHCID 823854-(Chlorosulfonyl)benzoic acid

Product 1

HCID 54018226HCID 54018226, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

In the temperature range from -10° C. to 0° C. and with stirring, a solution of 7.55 g of p-chlorosulfonylbenzoic acid in 25 g of tetrahydrofuran is slowly added to a solution of 5 g of α-hydroxyiminobenzyl cyanide in 24 g of tetrahydrofuran. The reaction mixture is heated, with stirring, to room temperature. After 2 hours, the reaction mixture is poured into 600 ml of 0.12N hydrochloric acid. The precipitated product is isolated by filtration, washed with water and dried at 40° C. in vacuo. Melting point: 250°-251° C.

Workup

  1. temperatureThe reaction mixture is heated
  2. stirringwith stirring, to room temperature
  3. customThe precipitated product is isolated by filtration
  4. washwashed with water
  5. customdried at 40° C. in vacuo

Sources & evidence

ORD record
ord-2d450c35908e47769fa0c09081f429f9
Source dataset
uspto-grants-1988_04
Patent number
US04736055

Reaction notes

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