反应详情

4 g 1-(4-Bromobutyl)-4,4-dimethyl-2,6-piperidin-dione, 3.15 g 1-(4-(1,1-dimethylethyl)-2-thiazolyl)-piperazine, 2.7 g K2CO3, 70 ml dimethylformamide and 20 ml water are stirred at room temperature for about 35 hours. The mixture is diluted with water, extracted twice with ether, the combined extracts are washed with water, dried (Na2SO4) and evaporated. The residue is recrystallized from hexane/ethyl acetate, whereby the title compound is obtained, m.p. 93°-94°. M.p. of the hydrochloride is 199°-201° (ethanol/ether).

1. extractionextracted twice with ether
2. washthe combined extracts are washed with water
3. dry with materialdried (Na2SO4)
4. customevaporated
5. customThe residue is recrystallized from hexane/ethyl acetate, whereby the title compound
6. customis obtained
7. customis 199°-201°