Potassium Carbonate → HCID 13490894, compound

HRID 649066Notes

Reaction equation

HRID 649066 reaction equation
[CH:1]1([N:12]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[C:13]([O:15]C(C2C=CC([N+]([O-])=O)=CC=2)C)=O)[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@H:4]([OH:5])[C@H:2]1[OH:3].C(=O)([O-])[O-].[K+].[K+].[CH3:45][NH:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH3:64]>CN(C)C=O>[CH:1]1([N:12]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[C:13]([N:46]([CH3:45])[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH3:64])=[O:15])[O:9][C@H:8]([CH2:10][OH:11])[C@@H:6]([OH:7])[C@H:4]([OH:5])[C@H:2]1[OH:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 75539N-MethyloctadecylamineHCID 22837660HCID 22837660, compound

Product 1

HCID 13490894HCID 13490894, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

3.1 g of the compound of Example 47 are dissolved in 50 ml of dimethylformamide and treated with 5.0 g of potassium carbonate. 1.8 g of N-methyloctadecylamine are added and the mixture is heated to 50° C. After the reaction has ended, the mixture is cooled to room temperature and filtered, the filtrate is evaporated in vacuo and the residue is purified by column chromatography (eluent toluene/isopropanol 10:1).

Workup

  1. temperaturethe mixture is cooled to room temperature
  2. filtrationfiltered
  3. customthe filtrate is evaporated in vacuo
  4. customthe residue is purified by column chromatography (eluent toluene/isopropanol 10:1)

Sources & evidence

ORD record
ord-17da0920942341d8b0fedf7e6a32fa20
Source dataset
uspto-grants-1988_04
Patent number
US04737488

Reaction notes

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