反应详情

To 1 liter of toluene were added 300 g of DL-N-benzyloxycarbonylglutamic acid, 48 g of paraformaldehyde and 12 g of p-toluenesulfonic acid monohydrate, and azeotropic dehydration was then carried out for 1 hour. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the oily substance thus obtained was dissolved in 500 ml of ethyl acetate, after which the resulting solution was washed with water and then dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure to obtain oily DL-3-benzyloxycarbonyl-4-(2-carboxyethyl)oxazolidin-5-one.

1. customAfter completion of the reaction
2. customthe solvent was removed by distillation under reduced pressure
3. customthe oily substance thus obtained
4. washafter which the resulting solution was washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. customthe solvent was removed by distillation under reduced pressure