1-(4-Fluorophenyl)piperazine → HCID 9845047, compound

HRID 649758Notes

Reaction equation

HRID 649758 reaction equation
Br[CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9](=[O:11])[C:8]2[N:12]([CH3:15])[CH:13]=[CH:14][C:7]=2[S:6]1(=[O:17])=[O:16].[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][CH:20]=1.C(=O)([O-])O.[Na+]>O1CCOCC1>[F:18][C:19]1[CH:20]=[CH:21][C:22]([N:25]2[CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][N:5]3[CH2:10][C:9](=[O:11])[C:8]4[N:12]([CH3:15])[CH:13]=[CH:14][C:7]=4[S:6]3(=[O:17])=[O:16])[CH2:27][CH2:26]2)=[CH:23][CH:24]=1

Participants

5

Reactant 3

HCID 752601-(4-Fluorophenyl)piperazineHCID 516892Sodium BicarbonateHCID 15550033HCID 15550033, compound

Product 1

HCID 9845047HCID 9845047, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A suspension of 54 mg (0.17 mmol) of Compound 17, 46 mg (0.25 mmol) of 1-(4-fluorophenyl)piperazine and 57 mg (0.68 mmol) of sodium hydrogencarbonate in 3.4 ml of dioxane was refluxed for 7 hours. Post treatment and purification were conducted as in Example 9, whereby 67 mg of the title compound were obtained (yield: 94%).

Workup

  1. temperaturewas refluxed for 7 hours
  2. customPost treatment and purification

Sources & evidence

ORD record
ord-5a21c9471a1a40ce9578d72349958649
Source dataset
uspto-grants-2001_08
Patent number
US06271223B1

Reaction notes

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