Anisole → HCID 135816418, compound

HRID 649938Notes

Reaction equation

HRID 649938 reaction equation
[NH2:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[NH:4][C:5]1[S:9][C:8]2[CH:10]=[CH:11][C:12]([CH3:14])=[CH:13][C:7]=2[C:6]=1[C:15](OC)=O.[CH3:23][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C1(OC)C=CC=CC=1>[Ti](Cl)(Cl)(Cl)Cl>[CH3:14][C:12]1[CH:11]=[CH:10][C:8]2[S:9][C:5]3[NH:4][C:3]4[CH:19]=[CH:20][CH:21]=[CH:22][C:2]=4[N:1]=[C:15]([N:27]4[CH2:28][CH2:29][N:24]([CH3:23])[CH2:25][CH2:26]4)[C:6]=3[C:7]=2[CH:13]=1

Participants

5

Reactant 3

HCID 7519AnisoleHCID 531671-MethylpiperazineHCID 18422238HCID 18422238, compound

Product 1

HCID 135816418HCID 135816418, compound

Reagents, catalysts & solvents 1

HCID 24193Titanium TetrachlorideCatalyst

Procedure

In the same manner as in Example 1 and using methyl 2-(2-aminoanilino)-5-methylbenzo[b]thiophene-3-carboxylate, 1-methylpiperazine, anisole and titanium tetrachloride, 2-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.

Sources & evidence

ORD record
ord-c511c19a92774efba52d11fbf6df2109
Source dataset
uspto-grants-2001_08
Patent number
US06271225B1

Reaction notes

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