Anisole → HCID 135816406, compound

HRID 649939Notes

Reaction equation

HRID 649939 reaction equation
[NH2:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[NH:4][C:5]1[S:9][C:8]2[CH:10]=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:7]=2[C:6]=1[C:16](OCC)=O.[CH3:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1.C1(OC)C=CC=CC=1>[Ti](Cl)(Cl)(Cl)Cl>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:7]2[C:6]3[C:16]([N:29]4[CH2:30][CH2:31][N:26]([CH3:25])[CH2:27][CH2:28]4)=[N:1][C:2]4[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=4[NH:4][C:5]=3[S:9][C:8]=2[CH:10]=1

Participants

5

Reactant 3

HCID 7519AnisoleHCID 531671-MethylpiperazineHCID 18422381HCID 18422381, compound

Product 1

HCID 135816406HCID 135816406, compound

Reagents, catalysts & solvents 1

HCID 24193Titanium TetrachlorideCatalyst

Procedure

In the same manner as in Example 1 and using ethyl 2-(2-aminoanilino)-6-methoxybenzo[b]thiophene-3-carboxylate, 1-methylpiperazine, anisole and titanium tetrachloride, 3-methoxy-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.

Sources & evidence

ORD record
ord-68199c2c501c4719af4c0d80d467f7a1
Source dataset
uspto-grants-2001_08
Patent number
US06271225B1

Reaction notes

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