N,N-Dimethylaniline → HCID 18422376, compound

HRID 649971Notes

Reaction equation

HRID 649971 reaction equation
[CH2:1]1[C:6]2[C:7]3[C:13](=O)[NH:12][C:11]4[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=4[O:9][C:8]=3[S:19][C:5]=2[CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)=O.CN(C)C1C=CC=CC=1.[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]/[C:37]([OH:39])=[O:38].[CH3:42][N:43]1[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]1>>[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]/[C:37]([OH:39])=[O:38].[CH3:42][N:43]1[CH2:48][CH2:47][N:46]([C:13]2[C:7]3[C:6]4[CH2:1][CH2:2][CH2:3][CH2:4][C:5]=4[S:19][C:8]=3[O:9][C:10]3[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=3[N:12]=2)[CH2:45][CH2:44]1

Participants

6

Reactant 5

HCID 949N,N-DimethylanilineHCID 24813Phosphorus oxychlorideHCID 531671-MethylpiperazineHCID 444972Fumaric AcidHCID 18422160HCID 18422160, compound

Product 1

HCID 18422376HCID 18422376, compound

Procedure

In the same manner as in Example 80 and using 1,2,3,4-tetrahydro-[1]benzothieno[2,3-b][1,5]benzoxazepin-12(11H)-one (0.6 g), phosphorus oxychloride (5 ml), N,N-dimethylaniline (0.14 ml), 1-methylpiperazine (10 ml) and fumaric acid (260 mg), 1,2,3,4-tetrahydro-12-(4-methylpiperazin-1-yl)-[1]benzothieno[2,3-b][1,5]benzoxazepine fumarate (575 mg) was obtained.

Sources & evidence

ORD record
ord-e7f2d00dfde3419290477d8342f8da76
Source dataset
uspto-grants-2001_08
Patent number
US06271225B1

Reaction notes

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