Potassium Carbonate → Ethyl 8-cyano-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

HRID 651290Notes

Reaction equation

HRID 651290 reaction equation
[C:1]([C:3]1[C:4](F)=[C:5]([CH:19]=[C:20]([F:23])[C:21]=1[F:22])[C:6]([C:8](=[CH:14][NH:15][CH:16]1[CH2:18][CH2:17]1)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:7])#[N:2].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[C:1]([C:3]1[C:21]([F:22])=[C:20]([F:23])[CH:19]=[C:5]2[C:4]=1[N:15]([CH:16]1[CH2:18][CH2:17]1)[CH:14]=[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:6]2=[O:7])#[N:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178471876HCID 178471876, compound

Product 1

HCID 18417531Ethyl 8-cyano-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of the crude product from step f, 27,6 g of K2CO3, and 80 ml of dimethylformamide are stirred at room temperature for 16 hours. The reaction mixture is poured on 750 ml ice/water and the precipitate is filtered off with suction, washed with 80 ml of cold methanol and dried.

Workup

  1. filtrationthe precipitate is filtered off with suction
  2. washwashed with 80 ml of cold methanol
  3. customdried

Sources & evidence

ORD record
ord-e91e3ed45e4c4d7da17e701152d1ca5f
Source dataset
uspto-grants-2001_08
Patent number
US06278013B1

Reaction notes

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