Hydrochloric Acid → HCID 69288519, compound

HRID 651334Notes

Reaction equation

HRID 651334 reaction equation
[CH2:1]([O:8][C:9](=[O:28])[C@H:10]([NH:20]C(OC(C)(C)C)=O)[CH2:11][C:12]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>C(OCC)(=O)C>[ClH:29].[CH2:1]([O:8][C:9](=[O:28])[C@H:10]([NH2:20])[CH2:11][C:12]([N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1)=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54123732HCID 54123732, compound

Product 1

HCID 69288519HCID 69288519, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of the title A compound, (2R)-(t-butyloxycarbonylamino)-4-morpholin-4-yl-4-oxobutyric acid benzyl ester (2.91 g, 7.42 mmol) in 50 mL of ethyl acetate is saturated with hydrogen chloride gas for 15 min. The reaction is sealed and stirred for 3 h at RT. The solvent is evaporated to afford 2.27 g (93%) of (2R)-amino-4-morpholin-4-yl-4-oxobutyric acid benzyl ester hydrochloride as a white solid.

Workup

  1. customThe reaction is sealed
  2. customThe solvent is evaporated

Sources & evidence

ORD record
ord-d880f356c6974b13836f78a4d3dbdd8e
Source dataset
uspto-grants-2001_08
Patent number
US06277987B1

Reaction notes

Loading…