反应详情

0.36 g of 2,6-dichloro-4-pyridinemethanol and 0.1 g of triethylamine were dissolved into 2 ml of THF, 0.12 g of acrylonitrile were added to the solution at room temperature, and stirring was conducted for 2 hours. After the reacted solution was left overnight at room temperature, ethyl acetate was added. The organic phase was washed with water, and was dried by adding sodium sulfate. The solvent was removed by evaporation, and the residue was purified by silica gel column chromatography to obtain 0.23 g of 2,6-dichloro-4-(2-cyanoethoxymethyl)pyridine (Compound No. 6).

1. additionwere added to the solution at room temperature
2. waitAfter the reacted solution was left overnight at room temperature
3. washThe organic phase was washed with water
4. customwas dried
5. additionby adding sodium sulfate
6. customThe solvent was removed by evaporation
7. customthe residue was purified by silica gel column chromatography