Tert-Butylamine → 4-tert-Butyl-2,6-diethylmorpholin-2-ol

HRID 652221Notes

Reaction equation

HRID 652221 reaction equation
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[O:6]1[CH:8]([CH2:9][CH3:10])[CH2:7]1>>[C:1]([N:5]1[CH2:7][CH:8]([CH2:9][CH3:10])[O:6][C:8]([CH2:9][CH3:10])([OH:6])[CH2:7]1)([CH3:4])([CH3:3])[CH3:2].[C:1]([N:5]([CH2:7][CH:8]([OH:6])[CH2:9][CH3:10])[CH2:7][CH:8]([OH:6])[CH2:9][CH3:10])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 78341,2-Epoxybutane

Product 2

HCID 201996064-tert-Butyl-2,6-diethylmorpholin-2-olYield 61%HCID 23423723HCID 23423723, compoundYield 30%

Procedure

tert-Butylamine (17.0 g, 0.23 mol) and 1,2-epoxybutane (50 g, 0.69 mol) were subjected to a reaction as described in Example 1 above. A 61% yield of 4-tert-butyl-2,6-diethyl-2-hydroxymorpholine was obtained along with a 30% yield of N-tert-butyl-bis-(2-hydroxybutyl)amine.

Sources & evidence

ORD record
ord-931f1536f6e746029d623b4272d786fa
Source dataset
uspto-grants-1987_06
Patent number
US04670557

Reaction notes

Loading…