Benzaldehyde → HCID 2768148, compound

HRID 653056Notes

Reaction equation

HRID 653056 reaction equation
[CH:1](=[O:8])[C:2]1C=CC=CC=1.NC(N)=S.[C:13]([O:19][CH2:20][CH3:21])(=[O:18])[CH2:14][C:15]([CH3:17])=O.[C:22]1([CH:28]2C(C(OCC)=O)=C[NH:31][C:30](=[S:39])[NH:29]2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(OC(=O)C)(=O)C>>[C:1]([N:29]1[CH:28]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:14]([C:13]([O:19][CH2:20][CH3:21])=[O:18])=[C:15]([CH3:17])[NH:31][C:30]1=[S:39])(=[O:8])[CH3:2]

Participants

6

Reactant 5

HCID 240BenzaldehydeHCID 7918Acetic AnhydrideHCID 8868Ethyl AcetoacetateHCID 2723790ThioureaHCID 12186839HCID 12186839, compound

Product 1

HCID 2768148HCID 2768148, compound

Procedure

Utilizing the general procedure of Example 2 and starting with benzaldehyde, thiourea and ethyl acetoacetate, ethyl 4-phenyl-3,4-dihydropyrimidine-2(1H)thione-5-carboxylate was prepared and then acylated with acetic anhydride to afford the title product as a solid (mp 142°-5° C.).

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-441a75bcb4de46bc9cef1e2ed70832ed
Source dataset
uspto-grants-1987_06
Patent number
US04675321

Reaction notes

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