反应详情

To a solution of 3-[(2-benzothiazolyl)methoxy]aniline (2.0 g) and triethylamine (0.79 g) in tetrahydrofuran (50 ml) at room temperature is slowly added a solution of ethane sulfonyl chloride (1.0 g) in tetrahydrofuran. The reaction is stirred for 1 hour. The mixture is filtered through a pad of Celite and silica gel and the solvent is removed in vacuo giving an oil. The oil is purified by HPLC and crystallized from hexane to give 1.4 g (51% yield) of product, m.p. 111°-113° C.

1. filtrationThe mixture is filtered through a pad of Celite and silica gel
2. customthe solvent is removed in vacuo
3. customgiving an oil
4. customThe oil is purified by HPLC
5. customcrystallized from hexane