Dimethylformamide → HCID 136037622, compound

HRID 653608Notes

Reaction equation

HRID 653608 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4](=[O:12])[N:3]=1.[CH2:13](Br)[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=O.CN(C)C=O>O>[C:16]1([C:14]2[N:1]=[C:2]3[C:11]4[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=4[NH:5][C:4](=[O:12])[N:3]3[CH:13]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 6259Phenacyl bromideHCID 119589434-aminoquinazolin-2-ol

Product 1

HCID 136037622HCID 136037622, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

1.61 g (0.01 mol) of 4-amino-2-quinazolinone and then 2.2 g (0.011 mol) of phenacyl bromide are added to 25 ml of dimethylformamide. The mixture is heated at 120° C. (external heating) for 3 hours, then left to cool and water is added. The brown precipitate formed is filtered out (1.34 g).

Workup

  1. temperature(external heating) for 3 hours
  2. waitleft
  3. temperatureto cool
  4. customThe brown precipitate formed
  5. filtrationis filtered out (1.34 g)

Sources & evidence

ORD record
ord-07ea7bf8f97b4f1a9673ea5d74580416
Source dataset
uspto-grants-1992_07
Patent number
US05128338

Reaction notes

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