Phosphorus oxychloride → HCID 15056485, compound

HRID 654153Notes

Reaction equation

HRID 654153 reaction equation
[CH3:1][O:2][CH2:3][C:4]1([CH3:24])[CH2:13][CH:12]([N:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]2=[O:20])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:21](=O)[NH2:22])[CH:10]=2)[O:5]1.O=P(Cl)(Cl)Cl>ClCCCl>[CH3:1][O:2][CH2:3][C:4]1([CH3:24])[CH2:13][CH:12]([N:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]2=[O:20])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:21]#[N:22])[CH:10]=2)[O:5]1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 15056489HCID 15056489, compound

Product 1

HCID 15056485HCID 15056485, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

A mixture of 2.98 g of 2-methoxymethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-carbamoylchroman, 2 ml of POCl3 and 200 ml of 1,2-dichloroethane is boiled for 45 min. Cooling and customary working up gives 2-methoxymethyl-2-methyl-4-(1,2-dihydro-2-oxo-1-pyridyl)-6-cyanochroman.

Workup

  1. temperatureCooling

Sources & evidence

ORD record
ord-ca5159ed42134bf3b7305f14ab02e546
Source dataset
uspto-grants-1992_07
Patent number
US05130322

Reaction notes

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