Ethyl formate → HCID 15718588, compound
Reaction equation
C(OCC)=O.[O-:6][CH2:7][CH3:8].[Na+].[Na].[CH3:11][O:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:14]=1[CH2:15][CH2:16]C[C:18]2=[O:23]>C1C=CC=CC=1.C(O)C>[CH:7]([CH:8]1[CH2:16][CH2:15][C:14]2[C:19](=[CH:20][CH:21]=[CH:22][C:13]=2[O:12][CH3:11])[C:18]1=[O:23])=[O:6]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 0 °C
Procedure
A solution of ethyl formate (20 ml, 0.37 mol) in anhydrous benzene (100 ml) is added to sodium ethoxide, prepared from sodium (8.34 g, 0.35 mol) and absolute ethanol, in anhydrous benzene (100 ml). The reaction mixture is cooled to about 0° C. and a solution of 5-methoxy-3,4-dihydronaphthalen-1(2H)-one (25 g, 0.14 mol) in anhydrous benzene (100 ml) is then slowly stirred in. By working up the mixture as described in J. Am. Chem. Soc., 1947, 69, 2942, the above indicated product is recovered (24.8 g); m.p. 68°-70° C.
Workup
- custom, 1947, 69, 2942, the above indicated product is recovered (24.8 g)
Sources & evidence
- ORD record
- ord-f21af3bf99e148df9600ece3bada1650
- Source dataset
- uspto-grants-1992_07
- Patent number
- US05130339
Reaction notes
Loading…